Using a MicroRNA to Shift the Makeup of Glioblastoma Subtypes

July 13, 2017

Glioblastoma multiforme (GBM) is an extremely aggressive and highly malignant brain cancer due to the fast reproduction of cells and the vast differences among the cells within a tumor. A team of researchers from Brigham and Women’s Hospital—including ABTA Scientific Advisory Council member, E. Antonio Chiocca and ABTA Scholar In Training Award winner Arun Kumar Rooj, PhD—have recently published a study that examines microRNA to distinguish between subtypes of GBM. For this study, the team identified a specific microRNA called miR-128. Although mir-128 is normally found in the brain, its levels change in tumors. They also found that altering the level of miR-128 in more aggressive subtypes of GBM can make the cells throughout the tumor more similar, making it easier to treat.

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