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Research Initiatives

Early Career Investigator Awards

In addition to our own grants, the ABTA provides funding for other early career investigator awards:

  • AACR-ABTA Scholar-in-Training Award
    • This award is presented during the American Association for Cancer Research (AACR) Annual Meeting to support the travel of early-career investigators presenting brain cancer research.
  • ABTA Young Investigator Award
    • This award is presented during the American Association of Neurological Surgeons (AANS) and the Congress of Neurological Surgeons (CNS) annual meetings to support the travel of two junior faculty members who are presenting their neuro-oncology research at the meetings.
  • Brain Tumor Epidemiology Consortium (BTEC) Junior Investigator Award
    • This award is given to two early-career investigators with an interest in epidemiology of tumors in the brain and central nervous system.
    • See the 2018 awardees


 

Brain Tumor Funders’ Collaborative

The Brain Tumor Funders’ Collaborative (BTFC) is a partnership among private philanthropic and advocacy organizations. The BTFC has supported three multi-million dollar projects, eleven biomarker feasibility studies, and is currently collaborating on a study of long-term survivors of glioblastoma.

Molecular and Clinical Factors of Long-Term Survival in Glioblastoma Patients
3 year update

Glioblastoma (GBM) is a very aggressive type of brain tumor and is one of the most lethal cancer types in adults. While nearly half of GBM patients die within a year of diagnosis, about 5 percent live more than five years after receiving their diagnosis. These patients are considered long-term survivors. Currently, it is known that long-term survivors tend to be younger, are more likely to have had a complete tumor resection and have favorable molecular markers (IDH mutation and/or MGMT methylation). All other factors that lead to long-term survivorship are unknown.

In order to find these factors, a large international consortium was formed and funded by the Brain Tumor Funders Collaborative. So far, 34 institutions have enrolled more than 300 patients. Molecular testing, imaging, and other tests from long-term and non-long-term survivors are being compared to identify patterns specific to the long-term survivors. Understanding how these patterns relate to survival will give scientists a better understanding of how GBM develops, as well as shed light on new strategies for treating all GBM patients.

Visit the BTFC website

 

Cold Spring Harbor Laboratory Brain Tumor Course

The ABTA is the official sponsor of the Cold Spring Harbor Laboratory brain tumor course, a one-week brain tumor course held every other year. This unique course provides a clinical overview and emphasizes the molecular mechanisms involved in the growth and development of brain tumors.

Learn more about Cold Spring Harbor Laboratory courses

 

CBTRUS

The Central Brain Tumor Registry of the United States was founded in 1992, after the ABTA conducted a two year study to determine the feasibility of a central registry for all primary brain tumor cases in the U.S. One of the reasons for our continued support of this registry is to ensure the availability of data on the incidence and prevalence of both non-malignant (benign) and malignant brain tumors. The ABTA continues to support the printing and distribution of the CBTRUS’ Statistical Reports on Primary Brain and Central Nervous System Tumors.

View the latest report

Low-Grade Glioma Registry

The ABTA provides research funding to build a low-grade glioma (LGG) patient registry. The intent of the registry is to determine germline (inherited) and somatic (non-inherited) genetic variants that may be associated with increased risk of LGG. The registry will also be used to look at response to treatment data and clinical outcomes within this patient population.

The study is being led by Elizabeth B. Claus, PhD, MD, Professor of Biostatistics; Director of Medical Research, School of Public Health; Director of Stereotactic Radiosurgery, Department of Neurosurgery, Brigham and Women’s Hospital.

For more information, contact the registry at glioma@yale.edu.