Glioma

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“Glioma” is a general term used to describe any tumor that arises from the supportive (“gluey”) tissue of the brain. This tissue, called “glia,” helps to keep the neurons in place and functioning well.

 

There are three types of normal glial cells that can produce tumors. An astrocyte will produce astrocytomas (including glioblastomas), an oligodendrocyte will produce oligodendrogliomas, and ependymomas come from ependymal cells. Tumors that display a mixture of these different cells are called mixed gliomas.

 

Tumors such as “optic nerve glioma” and “brain stem glioma” are named for their locations, not the tissue type from which they originate.

 

Location

The location of the tumor depends on the type of cells from which it originates.

 

Description

Three types of normal glial cells can produce tumors—astrocytes, oligodendrocytes, and ependymal cells. Tumors that display a mixture of these cells are called mixed gliomas.

  • Astrocytoma: Click here to learn more about astrocytomas, including juvenile pilocytic astrocytoma, low grade astrocytoma, anaplastic astrocytoma, or glioblastoma.
  • Ependymoma: Click here to learn more about ependymoma.
  • Mixed Glioma (also called Oligoastrocytoma): These tumors usually contain a high proportion of more than one type of cell, most often astrocytes and oligodendrocytes. Occasionally, ependymal cells are also found. The behavior of a mixed glioma appears to depend on the grade of the tumor. It is less clear whether their behavior is based on that of the most abundant cell type.
  • Oligodendroglioma: Click here to learn more about oligodendroglioma.
  • Optic Glioma: These tumors may involve any part of the optic pathway, and they have the potential to spread along these pathways. Most of these tumors occur in children under the age of 10. Grade I pilocytic astrocytoma and grade II fibrillary astrocytoma are the most common tumors affecting these structures. Higher-grade tumors may also arise in this location. Twenty percent of children with neurofibromatosis (NF-1) will develop an optic glioma. These gliomas are typically grade I, pilocytic astrocytomas. Children with optic glioma are usually screened for NF-1 for this reason. Adults with NF-1 typically do not develop optic gliomas.
  • Gliomatosis Cerebri: This is an uncommon brain tumor that features widespread glial tumor cells in the brain. This tumor is different from other gliomas because it is scattered and widespread, typically involving two or more lobes of the brain. It could be considered a “widespread low-grade glioma” because it does not have the malignant features seen in high-grade tumors.

The widespread nature of gliomatosis cerebri causes enlargement of any part of the brain it involves. This may include the cerebral hemispheres, or less often, the cerebellum or brain stem.

 

Symptoms

Symptoms vary based on tumor type:

  • Astrocytoma:Click here to learn more about astrocytoma symptoms.
  • Ependymoma: Click here to learn more about ependymoma symptoms.
  • Mixed Glioma (also called Oligoastrocytoma): The initial symptoms, including headache and nausea, usually are the result of increased pressure inside the brain. Vision problems, as well as changes in behavior and personality, are also fairly common in mixed glioma patients.
  • Oligodendroglioma: Click here to learn more about oligodendroglioma symptoms.
  • Optic Glioma: These tumors may cause few or no symptoms. Their placement along the optic nerve, however, can cause vision loss (depending on the location of the tumor) or strabismus (“crossed eyes”). Hormonal disturbance might also occur, causing developmental delay(s), early puberty, and other symptoms.
  • Gliomatosis Cerebri: Symptoms are often nonspecific and can include personality and behavioral changes, memory disturbance, increased intracranial pressure with headache and sometimes seizures.

Incidence

The incidence of this tumor varies by type.

 

Cause

Like many tumor types, the exact cause of glioma is not known.

 

Treatment

Treatment is based on tumor type:

  • Astrocytoma: Click here to learn more about treatment for astrocytoma.
  • Ependymoma: Click here to learn more about treatment for ependymoma.
  • Mixed Glioma (also called Oligoastrocytoma): Treatment may include surgery followed by radiation therapy, particularly if the tumor is high-grade. Chemotherapy will also generally be used in high-grade tumors.
  • Oliogdendroglioma: Click here to learn more about treatment for oligodendroglioma.
  • Optic Glioma: Careful observation may be an option for patients with stable or slow-growing tumors. Surgery might be recommended for a growing tumor which involves only the optic nerve. Radiation might be used for a tumor of the chiasm or other pathways. Local radiation and chemotherapy with radiation therapy are used for recurrent tumors. Patients with primary and/or recurrent tumors may wish to take part in a clinical trial.
  • Gliomatosis Cerebri: Treatment is less well defined because this tumor is so rare. Surgical removal is generally not attempted, because it is so widespread. Radiation and chemotherapy may be considered.

Learn more about different treatment options for brain tumors on our Treatment page.

 

Some glioma treatments are available through research studies called clinical trials. Click here to access TrialConnect®, the ABTA's clinical trial match service.