Signaling pathway suppresses brain tumor

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December 8, 2015

A research team at the University of Basel in Switzerland has identified that the Notch pathway, a cell-signaling pathway central to brain stem activity and previously associated with the growth of gliomas, actually suppresses the formation of glioma brain tumors. Based on these findings, the Notch pathway could potentially serve as a new therapeutic target and also a new diagnostic tool to get more reliable prognoses for the progression and patient survival of brain tumors.

"We found that … when activated, this [Notch] pathway actually suppresses the formation of some types of glioma," says Claudio Giachino, lead author of the study. The scientists discovered when the Notch pathway is inhibited, it results in the accelerated growth of glioma tumors and makes these tumors more aggressive.

The ABTA’s Alumni Research Network member, Justin Lathia, also contributed to the study.

For more information on the study, click here.