For Children with Brain Tumors, Next-Generation Sequencing May Lead to Different Diagnoses

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November 15, 2016

Sequencing is a process of comparing tumors to a patient’s normal tissue, to help identify mutations driving tumor growth and matching them with targeted therapies. UCSF is one of the few hospitals that do this process and they have been seeing positive results.

Recently, they tried a next-generation sequencing process on 31 patients. The testing on 25 of the patients confirmed the information of their pathology reports. However, 6 changed their diagnosis as a result of the genetic findings. These findings have changed the treatment plan for some of these patients. The process will help to put more patients on targeted therapies and precision medicine which can be less toxic for patients.

Pediatric tumors tend to have less mutations than adult tumors. These studies are hoping to better identify tumor genetics and learn how they operate.

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