Researchers at the University of California, San Diego studied a mutation of the epidermal growth factor receptor (EGFR), which may drive the growth of glioblastoma multiforme (GBM). EGFRs “live” on the cell surface and bind to protein ligands.
"We started our study because we think EGFRvIII - the most common EGF receptor (EGFR) mutant in GBM - causes cancer through an integrated series of events," said researcher Paul Mischel.
The researchers profiled several enhancers of EGFRvIII's and found that when silencing two transcription factors, or regulators of gene expression, GBM tumor growth stopped, both in cell cultures and in an animal model that mimics GBM.
This study, published in the current issue of Molecular Cell, adds to the body of scientific knowledge about GBMs.
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