Rare but Fatal Pediatric Brain Tumor May Be Stopped with New Molecule

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February 28, 2017

Researchers at Northwestern University have found a molecule that can kill an aggressive pediatric brainstem tumor called diffuse intrinsic pontine glioma (DIPG). This rare but fatal tumor affects about 300 children per year under the age of 10. 

A type of mutant protein is found in about 80% of these tumors. The inhibitor being tested blocks the interactions of these mutant proteins that drive DIPG progression, stopping tumor growth. Currently, this inhibitor is not approved, but early studies in mice are promising. With further testing, this could eventually lead to clinical trials.

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