New cancer treatment shows promise in lab trials

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July 2, 2015

According to, there have been promising signs of a new cancer treatment in lab trials. Researchers at Saint Louis University, led by Thomas Burris, have been studying two metabolic pathways that are favorable for cancer cells to get their energy. The first pathway, called the Warburg effect, increases the use of glucose and the other, lipogenesis, allows cells to make their own fats which gives these cells energy. By using a small molecule, SR9243, to turn down genes the researchers are able to stop these processes, which in turn limit the cancer cells’ energy eventually leading to cell death. “The team found SR9243 also seems to work on glioblastoma, a type of brain cancer that is very hard to treat. However, the drug is not able to cross the blood-brain barrier very effectively, so the challenge will be to find a way to help it to do that.


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